This study was designed Sofa Table to identify an immune-related gene signature (IRGS) associated with breast cancer (BC) patient outcomes.Transcriptomic data from 1411 BC patients in the TCGA and GEO databases were used to identify differentially expressed immune-related genes (DEIGs) when comparing BC tumor and normal tissue samples.We were able to construct a 27-gene IRGS that was able to effectively separate BC patients into high- and low-risk groups that corresponded to significant differences in overall and recurrence-free survival (OS and RFS, respectively).Besides, the relevance of this signature to immune response and immune cell infiltration of BC tumors was evaluated.These high- and low-risk BC patients were found to exhibit significantly different immune responses and functional enrichment.
We also identified patients in the high-risk group exhibited significantly reduced immune cell infiltration of tumors relative to Queen Upholstered Headboard low-risk patients.Together, the results of this analysis offer a novel overview of the immune microenvironment within BC tumors and highlight key immunological genes associated with patient survival outcomes.